23184
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23184
Fluka
Fmoc chloride
BioChemika, ≥99.0% (HPLC), for fluorescence
| Synonym: | 9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl |
| CAS Number: | 28920-43-6 |
| Linear Formula: | C15H11ClO2 |
| Molecular Weight: | 258.70 |
| Beilstein Registry Number: | 2279177 |
| EC Number: | 249-313-6 |
| MDL number: | MFCD00001138 |
| PubChem Substance ID: | 24853861 |
Description
| Application | Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis. |
| Other Notes | Reagent for the pre-column fluorescent derivatization of amino acids1,2,3 |
Properties
| grade | for fluorescence |
| product line | BioChemika |
| assay | ≥99.0% (HPLC) |
| mp | 61-64 °C |
| 62-64 °C(lit.) | |
| suitability | in accordance for fluorescence |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | LQ6250000 |
References
| Cited Reference | 1. S. Einarsson et al. Anal. Chem. 58, 1638, (1986) |
| 2. Furst, P., et al. J. Chromatogr. 499, 557, (1990) Abstract | |
| 3. Miller, E.J., et al. Anal. Biochem. 190, 92, (1990) Abstract | |
| reference | Carpino, L.A. and Han, G.Y., 9-Fluorenylmethoxycarbonyl amino-protecting group J. Org. Chem. 37, 3404, (1972) |
| L.A. Carpino Acc. Chem. Res. 20, 401, (1987) | |
| Gioeli, C. and Chattopadhyaya, J.B., The flouren-9-ylmethoxycarbonyl group for the protection of hydroxy-groups; its application in the synthesis of an octathymidylic acid fragment. J. Chem. Soc., Chem. Commun., 672, (1982) | |
| Koole, L.H, et al., Synthesis of phosphate-methylated DNA fragments using 9-fluorenylmethoxycarbonyl as transient base protecting group. J. Org. Chem. 54, 1657, (1989) | |
| Fieser | Fieser 3,145 / Fieser 4,237 |
| Aldrich MSDS 1, 948:B / Corp MSDS 1 (1), 1688:B / FT-IR 1 (2), 339:C / FT-IR 2 (2), 2938:A / FT-NMR 1 (2), 1336:B / IR-Spectra (2), 924:H / IR-Spectra (3), 1057:B / NMR-Reference 2 (2), 332:D / RegBook 1 (2), 1967:G / Sigma FT-IR 1 (2), 562:D / Structure Index 1, 316:C:4 |
